Centrophenoxine is a choline source that improves memory and mental functions. It further protects brain health by slowing the impacts of brain aging.

Other names of Centrophenoxine are Meclofenoxate or Lucidril. This nootropic is potent and has existed for over five decades.

Centrophenoxine was created in 1959 by French scientists as a treatment for Alzheimer’s disease and age-related cognitive decline.

Unlike in Europe where it is prescribed for the treatment of age-related memory loss, in the United States and Canada it is available over the counter as a dietary supplement because of its cognitive enhancing properties.


Centrophenoxine has a wide range of benefits for the brain and body.  The benefits include:

1.  Enhancing Memory and Learning

Centrophenoxine enhances the formation, storage, and recall of memories.

A study conducted on healthy elderly human as the subjects, centrophenoxine seemed to improve long-term memory creation and mental alertness.

Centrophenoxine has further shown to improve synaptic plasticity which enhances fluid intelligence, otherwise known as the ability to come up with solutions for problems without depending on acquired knowledge.

2. Exhibits Anti-Aging and Neuroprotective Traits

Centrophenoxine has shown to increase the lifespan of rat test subjects up to 50%.

According to research, centrophenoxine is a robust free radical scavenger and potent antioxidant which protects the brain from age-related decline, it’s an antioxidant and replenishes damaged cells.

Further, Centrophenoxine has proved to reduce piling of age pigment (lipofuscin) that accumulates gradually in neurons among other cells. The build-up of Lipofuscin has been shown to be tied to aging.

3. Improves Mood and Motivation

Studies suggest that centrophenoxine has a great anti-anxiety effect. Many users have reported that it enhances both mood and motivation, as well as its effects as a mild antidepressant.

4. Its Working Mechanism

Centrophenoxine is a combination of PCPA  also “para-chlorophenoxyacetic” and a manufactured version of DMAE (dimethylaminoethanol) modified to enhance absorption and improve its ability to penetrate the blood-brain barrier.

Even after years of research, the precise mode of action of centrophenoxine is still not understood entirely.

However, as soon as centrophenoxine penetrates the blood-brain barrier, it ultimately enhances the supply of acetylcholine in the synaptic vesicles.  This happens either by converting into an intercessor phospholipid which then makes acetylcholine or via breaking down into choline which is a precursor to acetylcholine.

Acetylcholine is a neurotransmitter strongly linked with memory and general cognitive functions. Centrophenoxine’s property of increasing acetylcholine levels is the primary means through which it functions as a nootropic.

Further, centrophenoxine enhances cognition functions through increasing the supply of oxygen and glucose to the brain. It also decreases the concentrations of cellular waste and toxins that in may affect cognition.

Bottom Line

Centrophenoxine is a proven, safe and effective nootropic supplement that significantly boosts memory, improves learning ability, increases concentration, and increases fluid intelligence.

It is also a popular anti-aging supplement that flushes toxins from cells and prevents age-related cellular damage.